MRCP-1 MCQ-test Apr04
01.
Antidepressant medications act as
A.
dopamine agonists.
B.
dopamine antagonists.
C.
monoamine agonists.
D.
monoamine antagonists
02. Soluble fibrinogen is acted upon by thrombin to form
insoluble fibrin. Aggregation of fibrin occurs due to:
A.
the removal of a negatively charged C-terminal peptide from
the gamma chain.
B.
the removal of a hydrophobic C-terminal fibrinopeptides from
the alpha, beta and gamma chains.
C.
the removal of negatively charged A and B fibrinopeptides.
D.
the removal of hydrophobic A and B fibrinopeptides.
03. A jaundiced 45-year old patient was found to excrete a
larger than normal amount of urobilin in his urine. Upon physical examination he
appeared to have an anemia. These findings are consistent with
A.
an inability to efficiently conjugate bilirubin in the liver.
B.
a sickle cell anemia crisis.
C.
a bile duct obstruction.
D.
an acute myocardial infarction.
04. In a poorly controlled type I diabetes, which of the
following is LEAST characteristic of the disease?
A.
hypercholesterolemia
B.
hypertriglyceridemia
C.
hyperglycemia
D.
ketosis
E. polyuria
05. Graves disease results from:
A.
insufficient dietary iodine.
B.
hypothalamic insufficiency.
C.
pituitary insufficiency.
D.
binding of an immunoglobulin to the TSH receptor on thyroid
cells.
06. A person suffering from Von Gierke's disease will
often produce ketone bodies because
A.
such persons suffer from hypoglycemia
B.
their blood glucose levels will often be low
C.
oxaloacetate is required for gluconeogenesis
D.
all of the above
07. The principal role of Vitamin E in the prevention of
oxidative damage is to
A.
oxidize metals to their less reactive state.
B.
potentiate the action of superoxide dismutase.
C.
reduce Vitamin C to its active oxidation state.
D.
terminate free radical chain reactions in lipid bilayers.
E.
repair lipids that have been oxidized.
08. The chemotherapeutic agent, methotrexate, is an inhibitor
of
A.
thymidylate synthase
B.
aspartate transcarbamoylase
C.
dihydrofolate reductase
D.
PRPP synthetase
E.
carbamoyl phosphate synthetase
09. In cystinosis there is a defect in the lysosomal cystine
transporter. This disorder is treated with the compound cysteamine (H2N-CH2-CH2-S-H).
It enters the lysosome via:
A.
diffusion through the lipid bilayer.
B.
the cystine transporter.
C.
the cysteine transporter.
D.
the lysine transporter.
E.
the ornithine transporter.
10. What is the major fuel used by liver in the early fasting
state?
A.
glucose
B.
amino acids
C.
ketone bodies
D.
fatty acids
E.
lactate
11. Mucopolysaccharide in bone acts as:
A.
an enzyme.
B.
the cement of collagen.
C.
a lubricant.
D.
the hard part of bone.
12. Hyponatraemia is usually found in all of following
EXCEPT:
A. Severe liver disease
B. Bronchial carcinoma
C. Cushings syndrome
D. Untreated congestive cardiac failure
E. Ingestion of ecstasy
13. Anti-diuretic hormone
A.
binds with prolactin
B.
is synthesized in hypothalamus
C.
inhibits pancreatic glucagon
D.
stimulates syntheis of catecholamines
14. Alkaptonurea is characterized by:
A.
increased urinary homocystine
B.
increased conjugated bilirubin
C.
increased serum phenylalanine
D.
excessive homogentisic acid in urine
E.
increased serum cholesterol
15. Hyperphosphatemia may occur in all of the following
conditions EXCEPT:
A.
bone metastases
B.
hypervitaminosis D
C.
milk-alkali syndrome
D.
acromegaly
E.
vitamin D deficiency
16. Which of the above steps in the mobilization of fatty
acids from adipose tissue is inhibited by insulin?
A.
formation of free fatty acids from triglycerides in adipose
tissue
B.
transport of free fatty acids from adipose tissue to liver.
C.
formation of fatty acyl CoA from free fatty acids and CoA in
the cytoplasm.
D.
formation of fatty acyl carnitine in the cytoplasm.
E.
formation of fatty acyl CoA from fatty acyl carnitine in the
mitochondria.
17. An important event in dissolution of blood clots is
proteolytic degradation of the fibrin network. To accomplish this process,
plasminogen has to be converted to plasmin. The rate of the conversion is
accelerated by
A.
increased concentration of plasminogen activator inhibitor.
B.
increased synthesis of cholesterol in the liver.
C.
availability of phospholipid and calcium ions on the platelet
membrane.
D.
administration of epsilon-aminocaproic acid.
E.
the presence of the fibrin clot surface.
18. Excess blood sugar levels would stimulate which of the
following processes in the liver?
A.
glycolysis
B.
the citric acid cycle
C.
glycogenesis
D.
glycogenolysis
E.
lipolysis
19. A ten year old boy presents with precocious puberty. His
cortisol and aldosterone levels are abnormally low, and ACTH and androgen levels
are abnormally high. His most likely problem is a defect in:
A.
17 alpha-hydroxyprogesterone.
B. P450 c21 hydroxylase.
C. the androgen receptor.
D. LH secretion.
E. ACTH production.
20. Untreated NIDDM patients, but NOT untreated IDDM
patients, generally have
A.
impaired signal transduction in the phosphorylation cascade
initiated by the insulin receptor tyrosine kinase.
B.
antibodies to intracellular cell surface antigens of the
Beta-cells.
C.
an adequate rate of insulin secretion in response to
increases in blood glucose levels.
D.
a significant incidence of albuminuria and microalbuminuria.