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1.Large 'v' wave in jugular venous pulse is present in all except (A) Pailmonary Stenosis (B) Pulmonary Hypertension (C) Arstial fibrillation (D) Tricuspid regurgitation.
  1. Cause of systolic hypertension only are all except (A) Aortic atherosclerosis (B)Cushing's syndrome (C) Thyrotoxicosis (D) Beri-Beri
  2. Valvular lesion most often resulting from myocardial infarction is (A) Aortic Stenosis (B) Mitral stenosis (C) Mitral regurgitation (D) Tricuspid regurgitation.
  3. In MI enzyme last to rise and remains elevated for longest duration is (A) SGOT (B) SGPT (C) LDH (D) Aldolase.
  4. EKG findings in pulmonary embolism are all except (A)Deep S1 (B)Left axis deviation (C) Incomplete right bundle branch block (D) Prominent Q3 and inversion of T3
  5. 'Snow flake' deposits at corneal margins are seen in (A) Toxocara canis (B) Loa loa (C) Toxoplasma gondii (D) Onchocera volvulus.
  6. Eschar is been in infection with all except (A) Rickettsial pox (B) Endemic typhus (C) Tick typhus (D) Scrub typhus.
  7. All are causes of shock due to third compartment losses except (A) Pancreatitis (B) Ascites (C) Intestinal obstruction (D) Severe burns.
  8. Orthostatic hypotension appears, when reduction in circulating blood volume is more than (A) 5% (B) 10% (C) 20% (D) 30%
  9. Characteristic feature of streptococcal pneumonia is (A)Pneumatocoeles (B) Interstitial pneumonia (C) Lack of constitutional symptoms (D) Bronchopneumonia.
  10. 'Wool sorter's disease' develops due to (A) Bacillus anthracis (B) Bysinosis (C) Pseudomonas mallei (D) Aspergillus fumigatus.
  11. Lung compliance is reduced in all except (A) Emphysema (B) Healed TB with scarring (C) Hyaline membrane disease (D) Healed pyothorax with pleural thickening.
  12. Following ovarian tumors are associated with pleural effusion except (A) Granulosa Theca cell tumors (B) Dysgerminoma (C) Fibroma (D) Cystadenoma.
  13. Which of the following is not a feature of chronic bronchitis (A) Severe dyspnea (B) Repeated respiratory insufficiency episodes (C) Cor pulmonale is common (D) Elastic recoil is normal.
  14. Commonest cause of 'renal papillary necreosis' is (A) Diabetic mellitus (B) Analgesic abuse (C) Sickle cell anemia (D) Acute ureteric obstruction.
  15. Commonest cause of adult nephrotic syndrome is (A) Diabetes mellitus (B) Minimal change disease (C) Membranous glomerulonephritis (D) Amyloidosis.
  16. Hypovolemic hyponatremia occurs is (A) Addison's disease (B)Cirrhosis (C) SIADH (D) Nephrotic syndrome.
  17. Commonest organism causing pancreatic absess is (A) Staph aureus (B) Strep pyogenes (C) e.coli (D) Proteus.
  18. All are features of parkinsonism (A) Tremor at rest first appears in hands & fingers (B) Short shuffling gait (C) Alterations in tendon reflexes (D) Micrographia.
  19. Which of the following drug can cause focal myopathy (A) Pentazocine (B) Corticosteroids (C) Penicillamine (D) Chloroquine
  20. Calculate the score from Glasgow coma scale from following description : Eye opening present when pinched, flexes body inappropriately to pain makes sounds examiner can not understand. (A) 3 (B) 7 (C) 9 (D)11
  21. 'Stork legs' are characteristic of (A) Freidreich's ataxia (B) Charcot's_Marie-Tooth disease (C) Syringomyelia (D) Paralysis agitans.
  22. Hypoglycemia with hyperinsulinism occurs in all (A) Extrapancreatic tumors (B)Insulin auatoimmunity (C) Sulphonylurea ingestin (D) Insulinoma.
  23. Cutaneous lesion seen especially in insulin resistant diabetics is (A) Diabetic dermopathy (B) Dermal atrophy (C) Acanthosis nigricans (D) Xanthelasma
  24. Serum calciton in is raised in which type of carcinoma of thyroid (A) Papillary CA (B) Follicular CA (C) Medullary CA (D) None of the above.
  25. Commonest fosrm of nonspecific autoimmune thyroditis is (A) de Quervain's thyroiditis (B) Lymphocytic subacute thyroiditis (C) Hashimoto's thyroiditis (D) Riedel's thyroiditis.
  26. Rouleaux formation by RBCs is seen in (A) Multiple myeloma (B)Hereditary spherocytosis (C) Sickle cell anemia (D) Anorexia nervosa.
  27. Myeloid to erythroid ratio is normal in all (A) Sideroblastic anemia (B)Multiple myeloma (C) Aplastic anemia (D) Myelofibrosis.
  28. Multiple myeloma is associated with all (A) Raised ESR (B) Hypercalcemia (C) Raised serum alkaline phosphatase (D) Anemia.
  29. Both PT and PTT are increased in (A) Thrombocytopenia (B) Vitamin K deficiency (C) Haemophilia A (D) von Willebrand's disease.
  30. Which of the following statement about 'addisonian pernicious anemia' is true (A) Results from dietary lack of vitamin B12 (B) Reticulocyte count is above 3% (C) Schilling test can diagnose addisonian permicious anemia in remission (D) Simultaneous administration of intrinsic factor with vitamin B12 improves anemia in disease of distal ileum.
  31. In which of the following there is purely T-cell immunodeficiency (A) Wiskott-Aldrich syndrome (B) Ataxia -telangiectasia (C) Adenosine deaminase deficiency (D) All of the above.
  32. Nephrocalcinosis is seen in (A) Medullary sponge kidney (B) Renal tubular acidosis (C) polycystic kidney (D) Renal tuberculosis.
  33. Cryoglobulinemia is found in association with all except (A) Multiple myeloma (B) Thalassemia (C) Infectious mononucleosis (D) Systemic lupus erythematosus.
  34. Causes of exudative pleural effusion are all excepst (A) Post primary tuberculosis (B) Rheumatoid arthritis (C) Mesothelioma (D) Cirrhosis.
  35. Lung carcinoma associated with hypertrophic pulmonary osteo-arthropathy is (A) Squamous cell CA (B) Adenocarcinoma (C) Small cell CA (D) Large cell CA
  36. Which of the following lung carcinoma is most responsive to cytotoxic combination chemotherapy (A) Squamous cell CA (B) Large cell CA (C) Adenocarcinoma (D) Small cell CA
  37. There is increased incidence of pulmonary tuberculosis in (A) Silicosis (B) Bagassosis (C) Asbestosis (D) Bysinossis.
  38. Echocardiogram in rheumatic mitral valve stenosis shows all of the following except (A) Increased EF slope (B) Paradoxial movement of posterior mitral leaflet (C) Thickened leaflets (D) Evidence of right ventricuar dilatation.
  39. Wide and fixed splitting of S2 is seen in (A) Atrial septal defect (B) Aortic stenosis (C) Ventricular septal defect (D) Pulmonary hypertension.
  40. Central cyanosis occurs in (A) Mitral stenosis (B) Pulmonary arteriovenous fistula (C) Pulmonary stenosis (D) Congestive heart failure.
  41. Most common cause of 'pulmonary eosinophilia' is (A) Aspergillosis (B) Candidiasis (C) Ascariasis (D) Filariasis.
  42. Minimum amount of fluid present in pleural cavity that can be demonstrated by x-ray is (A) 100 ml (B) 300 ml (C) 500 ml (D) 700 ml
  43. Alveolar underventilation typically occurs in (A) Kyphoscoliosis (B) Pulmonary embilism (C) Salicylate intoxication. (D) Interstitial lung disease.
  44. 'M' spike is usually seen in (A) Thymoma (B) Macroglobulinemia (C) Lymphoblastic leukemia (D) Alpha chain disease.
  45. Most accurate assessment of spleen size can be done by (A) Ultrasonography (B) C.T. scan (C) Hida scan (D) Colloid scan.
  46. Dysphagia to solids only present in (A) Scleroderma (B) Esophageal achalasia (C) Plummer-Vinson syndrome (D)Zenker's diverticulum.
  47. Ascites in cirrhosis is due to all except (A) Increased capillary hydrostatic pressure (B) Decreased ADH metabolism (C) Secondary hyperaldosteronism (D) Lymphatic obstruction in liver.
  48. Which of the following disease is not caused by antibody mediated cytotoxic reaction (A) Goodpasture's syndrome (B) Autoimmune thyroiditis (C) Pulmonary aspergillosis (D) Pernicious anemia.
  49. Tricuspid stenosis is usually associated with (A) Pulmonary stenosis (B) Mitral regurgitation (C) Aortic stenosis (D) Mitral stenosis.
  50. All are features of 'polyarteritis nodosa' (A) Hematuria (B) Hypertension (C) Tender thickened peripheral arteries (D) Eosinophilia.
  51. All are clinical features of disease of extra pyramidal system except (A) Lead pipe rigidity (B) Positive Rossolimos sign (C) Delay in initiation of movements (D) Athetosis.
  52. All are features of interstitial pulmonary fibrosis except (A) There is hypoxemia with hypercapnia (B) The hypoxemia results from ventilation perfusion imbalance (C) Patient usually presents with progressive dyspnea and non productive cough (D) Vital capacity is decreased.
  53. Heparin administration cause abnormality in following coagulation test except (A) Partial thromboplastin time (B) Prothrombin time (C) Thrombin generation time (D) Whole blood clot lysis test.
  54. 'Ash-leaf' macule is characteristic of (A)Tuberous sclerosis (B)Secondary syphilis (C) Oculocutaneous albinism (D) Alopecia areata.
  55. Enzyme terminal deoxynucleotidal transferase is present in (A) Lymphoblasts of ALL (B) Lymphoblasts of CLL (C) Mature lymphocyte (D) Hairy cell leukemia lymphocyte.
  56. Best screening test for haemophilia is (A)Partial thromboplastin time (B) Prothrombin time (C) Thrombin time (D) Clotting time
  57. All of the following clotting factors are vitamin K dependent except (A) XI (B) VII (C) VIII (D) IX
  58. Which of the following statement ragarding 'ultrasound' as a tool in the investigation of renal disease is true (A) Discriminate between silid masses and cystic lesions (B) Provide information about functional capacity of kidney (C) Demonstrate the outline of the ureters (D) Differentiate between bening and malignant prostatic enlargement.
  59. All are clinical features of 'diabetic neuropathy' except (A) Failure of ejaculation in male (B) Gustatory sweating of face (C) Sensory loss with sparing of vibratory sensation (D) Cardiorespiratory arrest.
  60. The karyotype for normal male is (A) 46 XY (B) 46 XX (C) 47 XXY (D) 46 X
  61. Serum inorganic phosphate level is normal in (A) Paget's disease (B) Hypoparathyroidism (C) Rickets (D) Renal failure.
  62. Heberden nodes are usually seen in (A) Dermatomyositis (B) Rheumatoid arthritis (C) Degenerative joint disease (D) Charcot's joint
  63. Single most consistent laboratory finding in rheumatoid arthritis is (A) Positive latex agglutination test (B) Raised ESR (C) Leukocytosis (D) Raised ASO titer.
  64. Cardiac lesion most commonly seen in rheumatoid arthritis is (A) Mitral stenosis (B) Mitral regurgitation (C) Aortic stenosis (D) Aortic regurgitation.
  65. The most consistent laboratory findings in osteoarthritis is (A)Raised ESR (B) Leukopenia (C) Rheumatoid factor is positive in 30% (D) None of the above.
  66. Commonest cardiac arrhythmia resulting from digitalis toxicity is (A) Second degree A-V block (B)Atrial ectopic beats (C) Ventricular ectopic beats (D) Paroxysmal supraventricular tachycardia.
  67. 'Reversed pulsus paradoxus' is a characteristic feature of (A) Coarctation of aorta (B) Constrictive pericarditis (C) Hypertrophic obstructive cardiomyopathy (D) Tetralogy of Fallot's
  68. Drug of choice in acute paroxysmal atrial tachycardia is (A) Digitalis (B) Quinidine (C) Procainamide (D) Verapamil.
  69. Chronic cor pulmonale most commonly results from (A) Chronic asthmatic bronchitis (B) Kyphoscoliosis (C) Primary pulmonary hypertension (D) Pheumoconiosis.
  70. Best screening test for Cushing's syndrome is (A) Plasma cortisol level (B) Plasma ACTH level (C) Urinary 17-ketosteroid excretion (D) Dexamethasone suppression test.
  71. Most sensitive test to assess the 'hypothalamicpituitary-adrenal function' is (A) Diurnal rhythm of cortisol secretion (B) Acth stimulation test (C) Plasma ACTH levels (D) Serum cortisol response to insulin induced hypoglycemia.
  72. Investigation of choice for the diagnosis of phaeochromocytoma is (A) Plain x-ray abdomen (B) Intravenous pyelography (C) CT scan (D) Isotope scan.
  73. Most common cause of Cushing's disease is (A) Adrenal cortex hyperplasia (B)Adernal cortex adenoma (C) Pituitary microadenoma (D) Adrenal carcinoma.
  74. Reactive hypoglycemia is caused by all except (A) Fructose intolerance (B) Galactosemia (C) Leucine sensitivity (D) Insulinoma.
  75. Central nystagmus is caused by all except (A) Myasthenia gravis (B) Syringobulbia (C) Multiple sclerosis (D) Cerebellar tumors.
  76. Bilateral signs of upper motor neurone lesion are present in (A) Superior sagittal sinus thrombosis (B)General paralysis of insane (C) Pontine haemorrhage (D) All of the above.
  77. Paralysis of foot and leg with or without paresis of arm, results from a lesion of (A)Anterior cerebral artery (B) Middle cerebral artery (C) Posterior cerebral artery (D) Basilar artery.
  78. Which of the following tumor has highest likelihood to metastasize to CNS (A) Melanoma (B) Lymphoma (C) Bronchogenic carcinoma (D) brest carcinoma.
  79. Which statement about 'wernicke's aphasia' is true (A) Lesion is in dominant inferior frontal convolution (B)Speech is sparse, slow and effortful (C) Comprehension of written and spoken language is severely impaired (D) Patient is aware of deficit.
  80. Which of the following is not a X-linked recessive disorder (A) Hemophilia (B) G-6-PD deficiency (C) Duchenne's dystrophy (D) von Willebrand's disease.
  81. Which of the following can lead to SIADH (A) Carbamazepine (B) Mechanical ventilation (C) Myxoedema coma (D) All of the above.
  82. High coagulative laser is/are (A) NdYAG (B)CO2 (C) Argon (D) All of the above.
  83. Polycythemia is defined as hematocrit of (A) > 75% (B) > 65% (C) 55% (D) 50%
  84. Mitral value prolapse is best diagnosed by (A) 2 D Echo (B) M-mode Echo (C) ECG (D) Coranary angiography.
  85. 'Silver wire' appearance of retinal vessels is seen in which grade of hypertensive retinopathy (A) Grade I (B) Grade II (C) Grade III (D) Grade IV.
  86. Serological test to assess the responsiveness to treatment in syphilis is (A) FTA-Abs (B) VDRL (C) TPI (D) Kahn's
  87. All of the following hormones raise blood sugar level except (A) Thyroxine (B) Glucagon (C) Adrenaline (D) Vasopressin.
  88. Episodic weakness is seen in all except (A) Hypokalemia (B) Hypophysphatemia (C) Myasthemia gravis (D) Myotonia congenita.
  89. Flapping tremor is seen in (A)Parkinsonism (B) Cerebellar disease (C) Hepatic failure (D) Thyrotoxicosis.
  90. In PA view the x-ray chest, right border of the heart is formed by all except (A) Superior vena cava (B) Inferior vena cava (C) Right atrim (D) Left artrial appendage.
  91. Treatement of choice for Kala Azar if standard regimen fails is (A) Double dose of antimony for 4-6 weeks (B) Pentamidine (C) Amphotericin B (D) Ethlstibamine
  92. Commonest cause for lower motor neurone facial nerve palsy is (A) Bell's palsy (B) Sarcoidosis (C) Ramsay Hune syndrome (D) Trauma.
  93. All of the following are seen in Addison's disease except (A) Neutroperia (B) Raised serum urea nitrogen (C)Hypoglycema (D) Hypocalcemia.
  94. All of the following changes are seen in sickle cell anaemia (A) Reticulocytosis (B)Serum iron is normal (C) Decreased MCV and MCHC (D) Raised serum LDH
  95. Metabolic alkalosis is seen in (A)Thiazide diuretics (B)Persistent vomitting (C) Ureterosigmoid anastomosis (D) Primary hyperaldosteronism.
  96. Posterior mitral valve leaflet is affected more than the anterior mitral leaflet in (A) Mitral stenosis (B) Rheumatic mitral regurgitation (C) Mitral valve prolapse (D) Parachute mitral valve.
  97. Which of the following statement about 'psoriatic arthritis' is not true. (A) Usually affects small joints hand & feet (B) Sausage shaped digits result from flexor tendon sheath inflammation (C) Arthritis is usually seronegative (D) Arthritis is symmetrical & polyarticular.
  98. Hematogenous abscesses in the brain usually affect the (A) Temporal lobe (B) Cerebellum (C) Parietal lobe (D) Frontal lobe

100.All of the following changes in lung function are seen with aging except (A) Increased ventilation perfusion mismatch (B)Decreased vital capacity (C) Decreased forced expitatory volume (D) Decreased functional residual capacity.

101.Drug of choice in malignant hypertension is (A) Diazoxide (B) Nitroprusside (C) Hydrallazine (D) Reserpine.

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